Application of technology

Automated inspection

InnoScan inspection machines apply three general technologies for automated inspection. The chart below depicts which technologies are used to detect particulate matter, cosmetic defect and closure integrity issue.

  • PARTICULATE MATTER
  • Closure integrity issues
  • COSMETIC DEFECTS

Particulate matter

Particulate matter is defined as fragment/particle external to the formulation process.

Particulate matter is typically considered as a critical defect due to the impact when injected into the body. Moreover, particulate matter could potentially host harmful microorganisms causing contamination of the product.

Typical material of particulate matter is fiber, glass, rubber/plastic and metal.

Closure integrity issues

Closure integrity issues are defined as breach of the sterile environment of the closed primary packaging material.

Closure integrity issues are typically considered as a critical defect due to the potential contamination of the product.

Typically, closure integrity breaches are seen on the glass barrel, cap, plunger area and stopper area.

Cosmetic defects

Cosmetic defects do not typically alter the product quality or the product efficacy. However, some cosmetic defects can potentially develop to a critical defect, e.g. from a deep scratch to a penetrating crack compromising the product sterility.

Common cosmetic defects are scratches, dirt or dust on the glass barrel and scratches or dents on the cap.

  • MATRIX SCAN
  • LINE SCAN
  • HVLD

Matrix Camera

Shape or pattern recognition

Matrix camera is a commonly used imaging technology in the industry, yet best known for the recreational application. The camera sensors are organized in a matrix (grid), hence the matrix camera composes images of objects in a similar manner as the human eye perceives.

For inspection, InnoScan applies matrix camera when shape or pattern recognition is required, e.g. inspection of cosmetic defects.

Camera sensors

The camera sensors are organized in a matrix.

Object

Image Construction

The matrix camera composes images of objects in a similar manner as the human eye perceives.

Line Scan Camera

For precision imaging purposes

Line scan camera is a high-resolution imaging technology used for precision imaging purposes. In contrast to matrix camera, the sensors of the line scan camera are organized in one single column and the camera is able to acquire several thousand lines per second. The image of a line scan is constructed by stitching the acquired lines together. The line scan camera is suitable for imaging moving objects and ‘unwrapping’ three dimensional surfaces into two dimensional images.

For inspection, InnoScan uses line scan camera for high-resolution imaging of defects to the size of 50 μm, e.g. inspection of particulate matter.

Camera Sensors

The sensors of the line scan camera are organized in one single column and the camera is able to take several thousands lines per second.

Moving Objects

Image construction

The line scan camera is suitable for imaging moving objects.

The line scan image is constructed by stitching the individual lines.

Cylindrical Surface

Image construction

For inspection purposes, the line scan camera can be used to make a perfect two dimensional image of a three dimensional container surface.

The line scan image is constructed by stitching the individual lines.

High-Voltage Leak detection

For detecting leaking cracks

High-Voltage Leak Detection (HVLD) is a robust method for detecting leaking crack in primary packaging material. The technology builds on the principle that glass is an isolator of the current, while the liquid/product is a conductor.

  • The Principle
  • Leaking Crack

The Principle

The high-voltage is applied by the dedicated electrodes on a desired area. In the unbroken glass the current measured by the reference electrode is small due to the resistance in the glass.

Leaking Crack

In the case where the closure integrity is broken by a crack, the system transforms to a short-circuit where the current traverses along the path of least resistance. In this case, the current measured at the reference electrode is larger compared with the case where the closure integrity is undamaged.

Application of technology

Automated inspection

Innoscan inspection machines apply three general technologies for automated inspection. The chart below depicts, which technology is used to detect particulate matter, cosmetic defect and closure integrity issue.

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InnoScan | Sødalsparken 11 | 8220 Brabrand | Denmark | Phone: +45 86 26 56 77 | Fax: +45 86 26 56 78 | E-mail: innoscan@innoscan.dk